Key result
Isolated CABG in patients with severe left ventricular dysfunction (EF <30%) yielded a 77.7% 5-year survival and significantly lower 1-year mortality compared to no revascularization (OR 0.36).
Why the study?
Does isolated CABG improve survival in patients with severe left ventricular dysfunction compared to nonrevascularized patients?
Population
7,841 patients who underwent isolated coronary artery bypass grafting between 1996 and 2001, stratified by…
Comparison
Isolated coronary artery bypass grafting in… vs Patients undergoing CABG with moderate or normal…
Design
Cohort
Follow-up
5 years
Authors
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CABG was associated with lower mortality in severe LV dysfunction; leaves open whether RCTs would confirm benefit over medical therapy.
Cohort (n=7,841)
Yes
Does isolated CABG improve survival in patients with severe left ventricular dysfunction compared to nonrevascularized patients?
Effect estimate: HR 1.98 (95% CI 1.49 to 2.62)
Absolute Event Rate: 77.7% vs 91.2%
p-value: p=<0.001
Isolated CABG in patients with severe left ventricular dysfunction (EF <30%) carries an acceptable perioperative mortality risk and provides a significant 1-year survival benefit compared to no revascularization.
Appoo et al. (2004) conducted a cohort in Coronary artery disease with left ventricular dysfunction (n=7,841). Isolated CABG in severe left ventricular dysfunction (EF <30%) vs. Isolated CABG in normal ventricular function (EF >50%) was evaluated on 5-year survival (HR 1.98, 95% CI 1.49 to 2.62, p=<0.001). Isolated CABG in patients with severe left ventricular dysfunction (EF <30%) yielded a 77.7% 5-year survival and significantly lower 1-year mortality compared to no revascularization (OR 0.36).
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