Key result
Novel pulmonary hypertension therapies target multiple biochemical mechanisms alongside emerging neurostimulation and acupuncture.
Why the study?
Pulmonary hypertension is a progressive and incurable disease, warranting a review of current treatments targeting underlying biochemical mechanisms as well as novel therapies like neurostimulation.
This narrative review outlines current and experimental pharmacological and non-pharmacological treatments for pulmonary hypertension.
Should not change pulmonary hypertension management; leaves open efficacy of neurostimulation and acupuncture pending trials.
Pulmonary hypertension (PH) is a severe and chronic disease characterized by increased pulmonary vascular resistance and remodeling, often precipitating right-sided heart dysfunction and death. Although the condition is progressive and incurable, current therapies for the disease focus on multiple different drugs and general supportive therapies to manage symptoms and prolong survival, ranging from medications more specific to pulmonary arterial hypertension (PAH) to exercise training. Moreover, there are multiple studies exploring novel experimental drugs and therapies including unique neurostimulation, to help better manage the disease. Here, we provide a narrative review focusing on current PH treatments that target multiple underlying biochemical mechanisms, including imbalances in vasoconstrictor-vasodilator and autonomic nervous system function, inflammation, and bone morphogenic protein (BMP) signaling. We also focus on the potential of novel therapies for managing PH, focusing on multiple types of neurostimulation including acupuncture. Lastly, we also touch upon the disease's different subgroups, clinical presentations and prognosis, diagnostics, demographics, and cost.
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Tsai et al. (2024) conducted a review in Pulmonary hypertension. Pharmacological and non-pharmacological therapies was evaluated. Current and novel therapies for pulmonary hypertension target multiple biochemical mechanisms, with emerging treatments including neurostimulation and acupuncture.
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