Why the study?
While low adherence to oral pulmonary hypertension therapies worsens outcomes, the impact and prevalence of diuretic adherence in patients managed for pre-capillary pulmonary hypertension remained less clear.
What is the rate of diuretic adherence and its association with clinical outcomes in patients with pre-capillary pulmonary hypertension?
Population
220 patients managed for pre-capillary PH
Design
Prospective, single-centre study
Key result
Low adherence to diuretics in patients with pre-capillary pulmonary hypertension was associated with a higher risk of serious clinical events (OR 1.86; 95% CI 1.03-3.39; p=0.04).
Authors
Loading...
Low diuretic adherence was associated with higher event risk in pre-capillary PH; leaves open whether adherence interventions improve outcomes.
Observational (n=220)
No
What is the rate of diuretic adherence and its association with clinical outcomes in patients with pre-capillary pulmonary hypertension?
Effect estimate: OR 1.86 (95% CI 1.03-3.39)
p-value: p=0.04
Low adherence to diuretics is common (39%) in patients with pre-capillary pulmonary hypertension and is associated with an increased risk of serious clinical events.
Bozec et al. (2025) conducted an observational in Pre-capillary pulmonary hypertension (n=220). Diuretic adherence vs. High/adequate adherence was evaluated on Serious clinical events (unplanned hospitalisations, disease progression and intensification of oral PH therapies) (OR 1.86, 95% CI 1.03-3.39, p=0.04). Low adherence to diuretics in patients with pre-capillary pulmonary hypertension was associated with a higher risk of serious clinical events (OR 1.86; 95% CI 1.03-3.39; p=0.04).