Multi-beat pressure-volume loop-derived right ventricular-pulmonary arterial coupling predicts transplant-free survival in patients with pulmonary arterial hypertension.
Does multi-beat pressure-volume loop-derived right ventricular-pulmonary arterial (RV-PA) coupling predict transplant-free survival in patients with pulmonary arterial hypertension?
RV-PA coupling is a physiologically grounded marker of disease severity and survival in PAH, potentially complementing traditional hemodynamic indices for risk stratification.
Extract In their article published in this issue of the European Respiratory Journal, Rosen et al. 1 elegantly demonstrated that multi-beat pressure–volume loop-derived right ventricular–pulmonary arterial (RV–PA) coupling predicts transplant-free survival in patients with pulmonary arterial hypertension (PAH). Their findings reinforce the growing recognition that RV–PA coupling is a physiologically grounded and robust marker of disease severity and clinical worsening and – as first described by our group, to the best of our knowledge, and in the largest well-characterised PAH-only cohort reported so far – also of survival, thereby potentially complementing the traditional haemodynamic indices used for risk stratification 2–4.
Yogeswaran et al. (Thu,) conducted a editorial in Pulmonary arterial hypertension (PAH). Multi-beat pressure-volume loop-derived right ventricular-pulmonary arterial (RV-PA) coupling was evaluated on Transplant-free survival. Multi-beat pressure-volume loop-derived right ventricular-pulmonary arterial coupling predicts transplant-free survival in patients with pulmonary arterial hypertension.