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February 1, 1997Biochimica et Biophysica Acta (BBA) - Gene Structure and ExpressionOpen Access

Characterization of human cyclooxygenase 2 gene promoter localization of a TGF-β response element

Xionghu Yang Fuxiang Hou Linda Taylor Péter Polgàr

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Abstract

We characterized 2.3 kb of 5'-flanking region of the human cyclooxygenase 2 gene and analyzed its promoter activity. We localized three positive and two negative cis-acting regulatory regions and a TGF-beta response region. Basal promoter activity was located between -77 and +99 bp. Maximal promoter activity was observed from -1838 to +99 bp. A TGF-beta response region was found between -454 and -288 bp. This region included an NF-I site. Electrophoretic mobility shift assays showed that TGF-beta caused a marked change in the pattern and intensity of this NF-I like protein complex.

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Yang et al. (1997) studied this question.

synapsesocial.com/papers/6a0d4385389a567298ba692b https://doi.org/10.1016/s0167-4781(96)00225-4

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