Key result
Treatment of rat renal mesangial cells with IL-1 beta or TNF alpha induced nitric oxide synthase, increasing cGMP formation and attenuating the contractile response to angiotensin II.
Why the study?
Does treatment with IL-1 beta or TNF alpha induce nitric oxide synthase and increase cGMP formation in rat renal mesangial cells?
Population
Rat renal mesangial cells
Comparison
Treatment with interleukin 1 beta or tumour… vs Untreated control cells
Design
Preclinical
Follow-up
24 hours
Authors
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Hypothesis-generating in rat mesangial cells; human studies required before any clinical relevance.
Does treatment with IL-1 beta or TNF alpha induce nitric oxide synthase and increase cGMP formation in rat renal mesangial cells?
IL-1 beta and TNF alpha induce a macrophage-type nitric oxide synthase in rat renal mesangial cells, leading to increased cGMP formation and attenuated contractile responses to angiotensin II.
Pfeilschifter et al. (1992) studied Rat renal mesangial cells. Interleukin 1 beta (IL-1 beta) or tumour necrosis factor alpha (TNF alpha) vs. Untreated control cells was evaluated on cGMP formation. Treatment of rat renal mesangial cells with IL-1 beta or TNF alpha induced nitric oxide synthase, increasing cGMP formation and attenuating the contractile response to angiotensin II.
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