TNF-alpha stimulates the production of L-arginine-derived nitric oxide in mesangial and vascular smooth muscle cells, activating soluble guanylate cyclase and increasing cGMP, which may contribute to the pathogenesis of septic shock.
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Should not alter septic shock management; hypothesis-generating for TNF-alpha/NO/cGMP signaling in mesangial cells.
Marsden et al. (1990) studied this question.
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