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This study aims to identify biomarkers linked to ARDS diagnosis and severity, and to evaluate their relationship with mortality.

C105-04 Alveolar Host-response Biomarkers Exhibit Paradoxical Associations With Severity and Outcomes in Acute Respiratory Distress Syndrome (ARDS)

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This study aims to identify biomarkers linked to ARDS diagnosis and severity, and to evaluate their relationship with mortality.
Analyzed a cohort of 306 critically ill patients admitted to the ICU at the University of Washington between 2014-2025.
Measured 25 host-response biomarkers using bronchoscopy with BAL within 7 days of ICU admission.
Evaluated differences in concentrations of biomarkers between ARDS and non-ARDS patients and their associations with mortality.
22 of 25 BAL biomarkers were elevated in ARDS patients (BH-adjusted P < 0.05).
Higher levels of CCL17 were associated with a 19% lower risk of death in ARDS patients (BH-adjusted P for interaction = 0.03).
Exploratory analyses indicated features linked to T-cell exhaustion in patients with low BAL CCL17.

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Randomized trial investigates biomarkers related to ARDS severity and outcomes in critically ill adults, highlighting complex associations.

Sathe et al. (2026) studied this question.

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Randomized trial investigates biomarkers related to ARDS severity and outcomes in critically ill adults, highlighting complex associations.