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This report focuses on the accurate diagnosis and successful treatment of primary mediastinal synovial sarcoma misdiagnosed as lymphoma.

A80-4-24 Mediastinal Synovial Sarcoma Initially Misdiagnosed as Lymphoma: A Multidisciplinary Diagnostic and Therapeutic Success

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Case report demonstrates accurate diagnosis and treatment of mediastinal synovial sarcoma, highlighting the importance of multidisciplinary care.

This report focuses on the accurate diagnosis and successful treatment of primary mediastinal synovial sarcoma misdiagnosed as lymphoma.
Described case of a 45-year-old female with a mediastinal mass diagnosed through multidisciplinary review.
Utilized repeat biopsy and immunohistochemistry for accurate identification of synovial sarcoma.
Facilitated complete resection followed by chemotherapy and surveillance.
Initial misdiagnosis led to treatment for lymphoma with partial response.
Correct diagnosis of spindle-cell synovial sarcoma confirmed by final histopathology.
Successful complete resection performed, with plans for adjuvant chemotherapy.

Cledera et al. (2026) studied this question.

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Case report demonstrates accurate diagnosis and treatment of mediastinal synovial sarcoma, highlighting the importance of multidisciplinary care.