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May 20, 2026American Journal of Health-System Pharmacy

Pediatric pharmacist antithrombotic interventions account for ~9% of accepted ICU interventions, mostly in the PCICU.

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Why the study?

Pharmacists manage antithrombotic therapy in critically ill adults, but data on the types of antithrombotic therapy interventions provided by pediatric pharmacists in critically ill children are limited.

What are the characteristics and frequencies of antithrombotic interventions provided by pediatric pharmacists in critically ill children?

Population

2,264 critically ill pediatric patients across 9 children's hospitals in the United States

Comparison

Pediatric pharmacist interventions recorded across ICU shifts

Design

Multicenter prospective observational study

Key result

Pediatric pharmacist antithrombotic interventions accounted for 9% of all accepted interventions in critically ill children, with 74.7% of these occurring in the pediatric cardiac intensive care unit.

Authors

AKAmy L. KiskaddonPJPeter N. JohnsonLDLexie Dallas

Discussion

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Overview

Antithrombotic interventions warrant focused pharmacist attention in pediatric cardiac ICUs; leaves open their effect on patient outcomes.

Key Points

  • To characterize antithrombotic therapy interventions provided by pediatric pharmacists in critically ill children.
  • Multicenter, prospective, observational study at 9 children's hospitals.
  • Data collection recorded recommendations during at least 20 shifts by 41 pharmacists.
  • Descriptive statistics summarized 12,632 accepted interventions during 697 shifts.
  • 1,130 (9%) of interventions were antithrombotic-related, involving 693 of 2,264 patients (26.4%).
  • Most interventions (74.7%) occurred in the PCICU with 844 out of 1,130 being in that unit.
  • Approximately 53.7% of antithrombotic interventions were related to initiation or management, primarily involving anticoagulant medications.

Study Design

Type

Observational (n=2,264)

Multicenter

Yes

Structured PICO

What are the characteristics and frequencies of antithrombotic interventions provided by pediatric pharmacists in critically ill children?

P
Population
2,264 critically ill children in the pediatric intensive care unit (PICU), neonatal intensive care unit (NICU), mixed intensive care unit (ICU), and pediatric cardiac intensive care unit (PCICU) at 9 children's hospitals in the United States.
I
Intervention
Pediatric pharmacist clinical interventions related to antithrombotic therapy
O
Outcome
Types and frequencies of antithrombotic therapy interventions provided by pediatric pharmacists

Pediatric pharmacists frequently provide antithrombotic therapy interventions in critically ill children, especially in the pediatric cardiac intensive care unit.

Cite This Study

Kiskaddon et al. (2026) conducted an observational in Critically ill children (n=2,264). Pediatric pharmacist antithrombotic interventions was evaluated on Types and frequency of antithrombotic therapy interventions provided by pediatric pharmacists. Pediatric pharmacist antithrombotic interventions accounted for 9% of all accepted interventions in critically ill children, with 74.7% of these occurring in the pediatric cardiac intensive care unit.

synapsesocial.com/papers/6a0d4f19f03e14405aa9a53ehttps://doi.org/10.1093/ajhp/zxag117
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