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B53-40 A Case of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Overlap: A Rare but Fatal Complication of a Common Medication

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Case report demonstrates SJS/TEN overlap management in a 27-year-old woman, highlighting critical intervention needs.

To report a rare case of Stevens-Johnson syndrome and toxic epidermal necrolysis overlap following lamotrigine treatment.
Case presentation of a 27-year-old woman with bipolar disorder treated with lamotrigine.
Multidisciplinary management involving dermatology, ophthalmology, urology, and otolaryngology.
Skin biopsy and direct immunofluorescence analysis were performed.
Patient presented with 25-30% total body surface area involvement of SJS/TEN overlap.
Despite severe symptoms, including fever and mucositis, she received specialized care and made a full recovery.
Aggressive interventions included fluid resuscitation, intravenous immunoglobulin, and transfer to a burn unit.

Das et al. (2026) studied this question.

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