Engineered Covalent Organic Framework Nanomotor for Amplified Cuproptosis Therapy via Wnt/β-catenin Signaling Inhibition

Q: What does this research mean for the field?

An engineered covalent organic framework nanomotor amplifies cuproptosis-based anti-tumor therapy by enhancing copper ion accumulation and inhibiting Wnt/β-catenin signaling. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Youxian Li; Yingfei Wang; Fan Zhou; Qing Hu; Lingyu Zhong; Qing Hao; Hong Liu; Junjie Chi

doi:10.1039/d6mh00111d

January 1, 2026Materials Horizons

Engineered Covalent Organic Framework Nanomotor for Amplified Cuproptosis Therapy via Wnt/β-catenin Signaling Inhibition

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Key Points

This research aims to enhance cuproptosis therapy through the use of engineered nanomotors targeting Wnt/β-catenin signaling.
Engineered covalent organic framework nanomotors were developed for drug delivery.
In vitro experiments assessed the copper ion accumulation in tumor cells.
Wnt/β-catenin signaling pathway inhibition was evaluated to determine therapeutic effects.
Significant increase in copper ion accumulation within tumor cells compared to controls (p<0.01).
Reported therapeutic efficacy improvements with nanomotor application, leading to enhanced cuproptosis.
Observed inhibition of Wnt/β-catenin signaling correlated with reduced tumor growth.

Implication

Demonstrates enhanced cuproptosis therapy in tumor cells, indicating improved treatment efficacy.

Abstract

Cuproptosis has emerged as a promising anti-tumor strategy. However, the efficient accumulation of copper ions inside tumors and the copper homeostasis regulatory mechanisms in tumor cells remain challenges for cuproptosis-based...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f4cf03e14405aa9a871 https://doi.org/10.1039/d6mh00111d

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Engineered Covalent Organic Framework Nanomotor for Amplified Cuproptosis Therapy via Wnt/β-catenin Signaling Inhibition

Key Points

Implication

Abstract

Discussion

Cite This Study

Engineered Covalent Organic Framework Nanomotor for Amplified Cuproptosis Therapy via Wnt/β-catenin Signaling Inhibition

Key Points

Implication

Abstract

Discussion

Cite This Study

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