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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B53-13 Thrombotic Overdrive: A Case of Catastrophic Antiphospholipid Syndrome Post VA-ECMO Decannulation

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Authors

KMK E MorilesSSS SparrowDMD Mcpherson

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Overview

Case report highlights inadequate anticoagulation leading to catastrophic antiphospholipid syndrome post VA-ECMO.

Key Points

  • This case report aims to present the occurrence of catastrophic antiphospholipid syndrome in a patient post VA-ECMO.
  • Detailed review of a 42-year-old female with a history of antiphospholipid syndrome post valve replacement on VA-ECMO.
  • Monitoring hemodynamics, anticoagulation strategies, and the progression of thrombosis after decannulation.
  • Administration of bivalirudin, plasma exchange, and rituximab for refractory CAPS.
  • Patient developed severe thrombosis and elevated CVP post decannulation despite anticoagulation.
  • Undiagnosed CAPS led to inadequate anticoagulation, worsening the patient's condition.
  • Compassionate withdrawal was opted by the family as the patient continued to decline.

Cite This Study

Moriles et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f4cf03e14405aa9a916https://doi.org/10.1093/ajrccm/aamag162.4825
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