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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C53-05 Persistent Encephalopathy Following Lithium Toxicity: SILENT Syndrome

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Authors

DTD ThotaSt. Joseph Medical CenterDAD AleemSt. Joseph Medical CenterBHB HernandezSt. Joseph Medical Center

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Implication

Randomized trial uncovers persistent neurological deficits in elderly patients post-lithium toxicity, suggesting a need for close monitoring.

Key Points

  • This report aims to highlight the occurrence of persistent neurological deficits, termed SILENT syndrome, following lithium toxicity.
  • Clinical case of a 70-year-old woman with a history of schizophrenia and renal impairment.
  • Diagnostic imaging including CT and MRI of the brain to assess structural changes.
  • Management involved IV fluids, psychiatric assessment, and monitoring of renal function.
  • Patient developed acute hypoxic respiratory failure, requiring intubation despite normalized lithium levels.
  • EEG showed diffuse slowing consistent with toxic-metabolic encephalopathy.
  • Diagnosis of probable SILENT was made due to persistent cognitive dysfunction after lithium normalization.

Cite This Study

Thota et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4f4cf03e14405aa9a975https://doi.org/10.1093/ajrccm/aamag162.3306
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C53-33 The SILENT Killer2026
  2. 2SILENT Syndrome – a Case of Lithium Neurotoxicity on Maintenance Therapy2024 · 1 citations
  3. 3The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity: A Report of Two Cases2025
  4. 4Lithium-induced neurotoxicity (SILENT Syndrome) in a Schizoaffective patient: A case of prolonged treatment leading to severe neurological complications2025
  5. 5Syndrome of Irreversible Lithium-Effectuated Neurotoxicity: Silent, but not innocent2024 · 1 citations