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This research examines the pharmacokinetics and anti-inflammatory properties of amygdalin epimers derived from Armeniacae semen amarum.

May 20, 2026Food & Function0 citations

Stereoselective Pharmacokinetics and Anti-inflammatory Activity of Amygdalin Epimers: Implications for Thermal and pH Stability in Amygdalin -Based Functional Foods

WLWenkang LiuShanghai University of Traditional Chinese Medicine XHXianrun HuShanghai University of Traditional Chinese Medicine MZMaojie ZhouShanghai University of Traditional Chinese Medicine

Key Points

This research examines the pharmacokinetics and anti-inflammatory properties of amygdalin epimers derived from Armeniacae semen amarum.
Analyzed the effects of thermal processing on epimerization of amygdalin.
Evaluated pharmacokinetic profiles and anti-inflammatory activities of different epimers in vitro.
Studied the implications of pH stability for functional food applications.
Epimerized amygdalin showed enhanced anti-inflammatory activity compared to non-epimerized forms.
Heat treatment significantly affected the pharmacokinetics of the compounds.
Optimal pH conditions improved stability and activity of the amygdalin epimers.

Abstract

Armeniacae semen amarum (ASA), the seed of Prunus armeniaca L, is widely consumed as both a food and a traditional medicinal ingredient. but thermal processing may induce epimerization of its...

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