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This report explores the rare occurrence of microsatellite instability-high non-small cell lung cancer and the implications for targeted immunotherapy.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

C79-14 Microsatellite Instability-high Lung Adenocarcinoma: Expanding the Frontier of Immunotherapy

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Authors

IPI PoojaryOakwood University MPM PapannaOakwood University TPT PatraOakwood University

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Implication

Case presentation shows dual immunotherapy effectiveness in rare MSI-H lung adenocarcinoma, suggesting new treatment pathways.

Key Points

This report explores the rare occurrence of microsatellite instability-high non-small cell lung cancer and the implications for targeted immunotherapy.
Case presentation of a 76-year-old female with metastatic lung adenocarcinoma and dual immune checkpoint inhibitor therapy initiated.
Extensive diagnostic evaluations including CT, PET-CT, and genetic testing to determine tumor characteristics and immunotherapy suitability.
Patient diagnosed with MSI-H metastatic lung adenocarcinoma initiated on nivolumab and ipilimumab treatment.
Tumor mutation burden was found to be 42.6 mut/Mb, indicating high neoantigen load and potential response to therapy.
Immunotherapy approach demonstrated a favorable clinical response despite PD-L1 negativity.

Cite This Study

Poojary et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fa9f03e14405aa9b06f https://doi.org/10.1093/ajrccm/aamag162.3983

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C79-14 Microsatellite Instability-high Lung Adenocarcinoma: Expanding the Frontier of Immunotherapy

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Cite This Study

C79-14 Microsatellite Instability-high Lung Adenocarcinoma: Expanding the Frontier of Immunotherapy

Discussion

Member takes

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Key Points

Cite This Study

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