What question did this study set out to answer?

The aim is to investigate how sulfatases regulate growth factor interactions with heparan sulfate and the mechanisms involved.

May 20, 2026ACS Chemical Biology

Human Sulfatases Use Dual Mechanisms to Control Growth Factor–Heparan Sulfate Interactions

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Authors

BTBryce M. TimmUniversity of California System JFJulianna L. FollmarUniversity of California System RPRyan N. PorellUniversity of California System

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Implication

Randomized trial examines dual mechanisms of sulfatases in modulating growth factor signaling via heparan sulfate, suggesting implications for development and disease.

Key Points

The aim is to investigate how sulfatases regulate growth factor interactions with heparan sulfate and the mechanisms involved.
Utilized bioengineered heparan sulfate conjugates with specific sulfation patterns.
Tracked enzyme binding and catalytic remodeling of heparan sulfate.
Analyzed two isoforms of sulfatases for their mechanisms of action.
Both sulfatases use catalytic desulfation and competitive binding to modulate growth factor interactions.
Mechanisms depend on the sulfation patterns of heparan sulfate and specific growth factors.
Differences in binding and desulfation behavior observed between the two sulfatase isoforms.

Cite This Study

Timm et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fbff03e14405aa9b2d7 https://doi.org/10.1021/acschembio.6c00368

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Implication

Randomized trial examines dual mechanisms of sulfatases in modulating growth factor signaling via heparan sulfate, suggesting implications for development and disease.

Human Sulfatases Use Dual Mechanisms to Control Growth Factor–Heparan Sulfate Interactions

Discussion

Member takes

Implication

Key Points

Cite This Study

Human Sulfatases Use Dual Mechanisms to Control Growth Factor–Heparan Sulfate Interactions

Discussion

Member takes

Implication

Key Points

Cite This Study

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