Synthesis of Functionalized 5-Cyclo- m -phenylenes Enabled by Controlled Multihalogenation Using a Carborane Catalyst

Key Points

• This research aims to explore efficient methods for functionalizing [5]-cyclo-m-phenylenes using carborane catalysts.
• Utilized controlled multihalogenation methods for synthesis.
• Performed benzylic bromination for initial functional group introduction.
• Achieved overall demethylation via decarboxylation processes.
• Successfully introduced diverse functional groups through nucleophilic substitution.
• Demonstrated effective overall transformation from carboxylic acid.
• Synthesis provides a versatile tool for future chemical applications.