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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C80-05 Beyond the Obvious: Pulmonary Light Chain Deposition Disease Presenting as Multiple Lung Nodules

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Authors

NDN Uma DwarakanathSSS Palasamudram ShekarRPR Pamu

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Overview

Case presentation reveals pulmonary light chain deposition disease in a 76-year-old female, indicating the need for better recognition and diagnosis of this rare condition.

Key Points

  • To highlight the presentation and diagnosis challenges of pulmonary light chain deposition disease (PLCDD).
  • Presented case of a 76-year-old female with cough and weakness, diagnosed through imaging and biopsy.
  • Used chest X-ray and CT scans to identify lung nodules; CT-guided biopsy confirmed light chain deposition.
  • Conducted mass spectrometry analysis to distinguish between PLCDD and malignancy.
  • CT scans revealed multiple bilateral pulmonary nodules with bronchocentric distribution; biopsy showed non-malignant material.
  • Mass spectrometry indicated presence of kappa light chain deposition without malignancy, confirming PLCDD diagnosis.
  • Recommended further hematologic workup for possible chemotherapy or stem cell therapy.

Cite This Study

Dwarakanath et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fd2f03e14405aa9b574https://doi.org/10.1093/ajrccm/aamag162.3998
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