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August 20, 2026International Journal of Surgical Pathology

Pulmonary Light Chain Deposition Disease in a Patient With Chronic Lymphocytic Leukemia

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Authors

TWTaylor L. WilsonJPJacqueline E. PaytonMSMark A. Schroeder

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Overview

Case report reveals isolated pulmonary light chain deposition disease in chronic lymphocytic leukemia, indicating potential non-leukemic clonal immunoglobulin production.

Key Points

  • To report and characterize a rare case of isolated pulmonary light-chain deposition disease in a patient with chronic lymphocytic leukemia.
  • Evaluated a 73-year-old female with untreated IgG-kappa chronic lymphocytic leukemia presenting with B-symptoms and a 1-cm FDG-avid right lower lobe lung nodule (N=1).
  • Performed wedge resection followed by histopathologic evaluation, mass spectrometry, flow cytometry, and IGH clonality analysis.
  • Histopathology and mass spectrometry identified Congo red-negative eosinophilic deposits composed of kappa immunoglobulin light chains.
  • Flow cytometry and IGH clonality analysis demonstrated minimal clonal overlap between the lung-infiltrating lymphocytes and the patient's systemic leukemia clone.

Cite This Study

Wilson et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5da8a91293e6a1cd6f6https://doi.org/10.1177/10668969261467682
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C80-05 Beyond the Obvious: Pulmonary Light Chain Deposition Disease Presenting as Multiple Lung Nodules2026
  2. 2[Pulmonary light chain deposition disease from a respiratory physician's perspective].2024
  3. 3A40-54 Cracking the Case of Popcorn Nodules: Isolated Pulmonary Light Chain Deposition Disease2026
  4. 4Pulmonary light chain deposition disease: Case series and review of the literature2024 · 1 citations
  5. 5Light chain deposition disease masquerading as hypophosphatemic osteomalacia: a case report2026