What question did this study set out to answer?

This research aims to understand the inflammatory mediators and microbiological profiles associated with bronchiectasis in patients with alpha-1 antitrypsin deficiency.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

B45-34 Inflammatory Cytokine, Protease and Microbiological Profiles in Alpha-1 Antitrypsin Deficiency Associated Bronchiectasis: Interim Findings and Ongoing Translational Analysis

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This research aims to understand the inflammatory mediators and microbiological profiles associated with bronchiectasis in patients with alpha-1 antitrypsin deficiency.
Enrolled 13 participants (10 AATD, 3 non-AATD controls) with CT classification into four groups.
Conducted bronchoalveolar lavage for inflammatory analysis and microbiological assessment.
Performed shotgun metagenomic sequencing for airway microbiome characterization.
Minimal neutrophil elastase activity overall, with three patients showing higher levels correlated with BSI scores.
Elevated interleukin-6 and interleukin-1β concentrations linked to increased BSI and BODE scores.
Four AATD participants were culture-positive for various pathogens, indicating significant infection.

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Implication

Randomized trial investigates inflammatory profiles and disease severity in AATD bronchiectasis, suggesting cytokine involvement.

Cite This Study

Quigley et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fecf03e14405aa9b6d5 https://doi.org/10.1093/ajrccm/aamag162.1845

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B45-34 Inflammatory Cytokine, Protease and Microbiological Profiles in Alpha-1 Antitrypsin Deficiency Associated Bronchiectasis: Interim Findings and Ongoing Translational Analysis

Key Points

Discussion

Implication

Cite This Study

B45-34 Inflammatory Cytokine, Protease and Microbiological Profiles in Alpha-1 Antitrypsin Deficiency Associated Bronchiectasis: Interim Findings and Ongoing Translational Analysis

Key Points

Discussion

Implication

Cite This Study

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