The Effect of a Primary Care Practice–Based Depression Intervention on Mortality in Older Adults

Letters5 February 2008The Effect of a Primary Care Practice–Based Depression Intervention on Mortality in Older AdultsJoseph J. Gallo, MD, MPH, Knashawn Morales, ScD, Edward Post, MD, PhD, Hillary Bogner, MD, MCSE, Julia Lin, PhD, and Martha Bruce, PhD, MPHJoseph J. Gallo, MD, MPHFrom the University of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this author, Knashawn Morales, ScDFrom the University of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this author, Edward Post, MD, PhDFrom the University of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this author, Hillary Bogner, MD, MCSEFrom the University of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this author, Julia Lin, PhDFrom the University of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this author, and Martha Bruce, PhD, MPHFrom the University of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-3-200802050-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Drs. Thombs and Ziegelstein's observation that our study was of great importance in reporting the beneficial effect of a depression intervention on mortality. Drs. Thombs and Ziegelstein were concerned that the post hoc selection of covariates for inclusion only if they were associated with the outcome led to overfitting and ignored the issue of confounding. We had a prespecified approach to identifying and including potential confounders because we knew that imbalances would be likely and that adjustment with patient-level variables would be necessary given the practice-randomized design. Our prespecified approach did address the concern about confounding ... Author, Article, and Disclosure InformationAffiliations: From the University of Pennsylvania, Philadelphia, PA 19104.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effect of a Primary Care Practice–Based Depression Intervention on Mortality in Older Adults Joseph J. Gallo , Hillary R. Bogner , Knashawn H. Morales , Edward P. Post , Julia Y. Lin , and Martha L. Bruce The Effect of a Primary Care Practice–Based Depression Intervention on Mortality in Older Adults Brett D. Thombs and Roy C. Ziegelstein Metrics Cited ByThe association between race and gender, treatment attitudes, and antidepressant treatment adherenceAcademic psychiatryʼs responsibility for increasing the recognition of mood disorders and risk for suicide in primary care 5 February 2008Volume 148, Issue 3Page: 245KeywordsClinical trial reportingConflicts of interestElderlyForecastingMyocardial infarctionObservational studies ePublished: 5 February 2008 Issue Published: 5 February 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...