Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 20, 2026American Journal of Respiratory and Critical Care Medicine

D95-08 Emergence of Distinct Pathologic Basal Cell Sub-types in Lung Fibrosis Mediated by Senescence

View Full Paper
Ask AI
Bookmark
Share

Authors

RNR P NaikawadiMYM YangABA Bhattacharyya

Discussion

Loading...

Member takes

Overview

Randomized trial examines lung remodeling and fibrosis in mice with telomere dysfunction, suggesting new insights for idiopathic pulmonary fibrosis.

Key Points

  • This study aims to investigate the role of telomere dysfunction in lung fibrosis and the associated cellular changes.
  • Used wild type and TRF1 floxed mice for experiments.
  • Administered low dose bleomycin post-tamoxifen injections to induce lung injury.
  • Analyzed lung tissue using single cell RNA-sequencing and histological techniques.
  • Telomere dysfunction combined with bleomycin resulted in non-resolving fibrosis.
  • TRF1-Bleo group showed 6-fold lower AT2 and 4-fold higher basal cell proportions compared to controls.
  • Krt15+ and Krt14+ basal cell populations linked to fibrosis were identified.

Cite This Study

Naikawadi et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5078f03e14405aa9c344https://doi.org/10.1093/ajrccm/aamag162.2891
View Full Paper
Ask AI
Bookmark
Share