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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C77-22 Driver Mutation and PD-L1 Expression Were Associated With Postoperative Recurrence and Survival in Stage I Non-small Cell Lung Cancer After Complete Resection

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Authors

CYC Yeo

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Overview

Randomized trial links driver mutations and PD-L1 expression to survival outcomes in stage I NSCLC, suggesting targeted monitoring.

Key Points

  • This research investigates how driver mutations and PD-L1 expression influence recurrence and survival in stage I non-small cell lung cancer (NSCLC) after surgery.
  • Analyzed data from the lung cancer registry at Catholic Medical Center, Seoul.
  • Included patients with histologically confirmed stage I NSCLC who underwent surgical resection from January 2017 to December 2021.
  • Investigated clinicopathologic factors affecting disease-free survival (DFS) and overall survival (OS).
  • Disease recurrence occurred in 56 patients (10.0%) out of 560 who had complete surgical resection.
  • Age≥65 (p=0.009), ECOG≥2 (p=0.020), driver mutations (EGFR, ALK, ROS) (p=0.025), and PD-L1 expression≥50% (p=0.001) were independent factors associated with poor OS.
  • The presence of driver mutations was a significant risk factor for predicting death, regardless of PD-L1 expression.

Cite This Study

C Yeo (2026) studied this question.

synapsesocial.com/papers/6a0d5089f03e14405aa9c5d0https://doi.org/10.1093/ajrccm/aamag162.3929
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