What does this research mean for the field?

Extremes of body mass index (both high and low) 5 years post-lung transplant are associated with poorer physical quality of life and increased depression compared to a normal BMI. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to explore the association between extremes of body mass index and patient-centered outcomes in lung transplant recipients.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

C47-23 Extremes of Body Mass Index (BMI) Are Associated With Poorer Physical Health and Increased Depression 5 Years Post-Lung Transplant: A Lung Transplant Outcomes Group Cohort Study

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Why the study?

Obesity is associated with worse patient-centered outcomes in chronic respiratory disease, but whether this association exists in lung transplant recipients is unknown.

Are extremes of BMI associated with poorer physical health and increased depression in lung transplant recipients 5 years post-transplant?

Comparison

BMI as a continuous variable

Design

Multicenter cross-sectional cohort study

Follow-up

Median 5.0 years

Key result

Body mass index extremes 5 years post-lung transplant were associated with poorer physical quality of life (-4.93 for BMI 18.5) and increased depression (+2.40 for BMI 34) versus a BMI of 24.

Authors

CFC E Fishman KPK Pandya IHI Hollin

Discussion

Member takes

Overview

Underweight status was associated with lower physical QoL; leaves open whether nutritional interventions improve outcomes in respiratory cohorts.

Key Points

The aim is to explore the association between extremes of body mass index and patient-centered outcomes in lung transplant recipients.
Cross-sectional analysis of adult lung transplant recipients from 7 US centers.
Participants completed assessments including Short Physical Performance Battery and multiple questionnaires 5 +/- 1 years post-transplant.
Mixed effects linear regression analyzed BMI's relationship with physical and mental health outcomes.
167 subjects provided data on physical health and BMI at a median of 5.0 years post-transplant.
Subjects with a BMI of 18.5 kg/m2 reported significantly lower physical quality of life (SF-12 PCS -4.93, 95% CI -9.73 to -0.14) and higher depression levels (PHQ-8 1.75, 95% CI -0.25 to 3.75).
Those with a BMI of 34 kg/m2 showed lower SF-12 PCS (-1.28, 95% CI -4.56 to 2.01) and higher depression scores (PHQ-8 2.40, 95% CI 1.05 to 3.74).

Structured PICO

Are extremes of BMI associated with poorer physical health and increased depression in lung transplant recipients 5 years post-transplant?

Population

167 adult lung transplant recipients enrolled in the Lung Transplant Outcomes Group cohort at 7 US centers, alive 5 +/- 1 years post-transplant, who completed the Short Physical Performance Battery (SPPB) or at least one questionnaire (SF-12, LT-VLA, PHQ-8). Median age 57, 59% male.

Intervention

Extremes of Body Mass Index (BMI) (evaluated as a continuous variable)

Comparator

Normal BMI (reference of 24 kg/m2)

Outcome

Physical health-related QoL (SF-12 PCS), mental HRQoL (SF-12 MCS), disability (LT-VLA), depression (PHQ-8), and frailty (SPPB)patient reported

In lung transplant recipients 5 years post-transplant, both low and high BMI are associated with poorer self-perceived physical quality of life and greater depression.

Cite This Study

Fishman et al. (2026) studied this question. Body mass index extremes 5 years post-lung transplant were associated with poorer physical quality of life (-4.93 for BMI 18.5) and increased depression (+2.40 for BMI 34) versus a BMI of 24.

synapsesocial.com/papers/6a0d5089f03e14405aa9c66a https://doi.org/10.1093/ajrccm/aamag162.6635

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May 20, 2026American Journal of Respiratory and Critical Care Medicine

C47-23 Extremes of Body Mass Index (BMI) Are Associated With Poorer Physical Health and Increased Depression 5 Years Post-Lung Transplant: A Lung Transplant Outcomes Group Cohort Study

View Full Paper

Ask AI

Bookmark

Why the study?

Obesity is associated with worse patient-centered outcomes in chronic respiratory disease, but whether this association exists in lung transplant recipients is unknown.

Are extremes of BMI associated with poorer physical health and increased depression in lung transplant recipients 5 years post-transplant?

Comparison

BMI as a continuous variable

Design

Multicenter cross-sectional cohort study

Follow-up

Median 5.0 years

Key result

Body mass index extremes 5 years post-lung transplant were associated with poorer physical quality of life (-4.93 for BMI 18.5) and increased depression (+2.40 for BMI 34) versus a BMI of 24.

Authors

CFC E Fishman KPK Pandya IHI Hollin

Discussion

Member takes

Overview

Underweight status was associated with lower physical QoL; leaves open whether nutritional interventions improve outcomes in respiratory cohorts.

Key Points

The aim is to explore the association between extremes of body mass index and patient-centered outcomes in lung transplant recipients.
Cross-sectional analysis of adult lung transplant recipients from 7 US centers.
Participants completed assessments including Short Physical Performance Battery and multiple questionnaires 5 +/- 1 years post-transplant.
Mixed effects linear regression analyzed BMI's relationship with physical and mental health outcomes.
167 subjects provided data on physical health and BMI at a median of 5.0 years post-transplant.
Subjects with a BMI of 18.5 kg/m2 reported significantly lower physical quality of life (SF-12 PCS -4.93, 95% CI -9.73 to -0.14) and higher depression levels (PHQ-8 1.75, 95% CI -0.25 to 3.75).
Those with a BMI of 34 kg/m2 showed lower SF-12 PCS (-1.28, 95% CI -4.56 to 2.01) and higher depression scores (PHQ-8 2.40, 95% CI 1.05 to 3.74).

Structured PICO

Are extremes of BMI associated with poorer physical health and increased depression in lung transplant recipients 5 years post-transplant?

Population

Intervention

Extremes of Body Mass Index (BMI) (evaluated as a continuous variable)

Comparator

Normal BMI (reference of 24 kg/m2)

Outcome

Physical health-related QoL (SF-12 PCS), mental HRQoL (SF-12 MCS), disability (LT-VLA), depression (PHQ-8), and frailty (SPPB)patient reported

In lung transplant recipients 5 years post-transplant, both low and high BMI are associated with poorer self-perceived physical quality of life and greater depression.

Cite This Study

synapsesocial.com/papers/6a0d5089f03e14405aa9c66a https://doi.org/10.1093/ajrccm/aamag162.6635

Also Consider

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