A29-06 Effect of Pulmonary Hypertension on Exercise Capacity in Patients With Interstitial Lung Disease: A Systematic Review and Meta-Analysis

R Torres-Castro; N Lopes Cardoso; X Alsina-Restoy; R Perez Rojo; J Tenes Mayen; G Perez PeÑate; D Badenes Bonet; A Garcia Ortega; D Rodríguez-Plaza; M Molina-Molina; I Blanco; V Resqueti; D Rodriguez

doi:10.1093/ajrccm/aamag162.2225

May 1, 2026American Journal of Respiratory and Critical Care Medicine

A29-06 Effect of Pulmonary Hypertension on Exercise Capacity in Patients With Interstitial Lung Disease: A Systematic Review and Meta-Analysis

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Key Points

To quantify how pulmonary hypertension affects exercise capacity in patients with interstitial lung disease.
Included studies using the six-minute walk test (6MWT) or cardiopulmonary exercise testing (CPET) in ILD patients.
Compared exercise tolerance in patients with pulmonary hypertension (ILD-PH) and without (ILD-non-PH).
Screened 2,410 records to include 29 studies with 5,712 participants.
ILD-PH patients walked 76.9 meters less in the 6MWT than ILD-non-PH (95% CI: -100.7 to -53.1; p < 0.0001).
In idiopathic pulmonary fibrosis, patients with PH reduced walking by 69.0 meters (95% CI: -96.8 to -41.2; p < 0.0001).
Peak oxygen uptake (VO2peak) was lower by 3.89 ml/min/kg in ILD-PH patients compared to ILD-non-PH (95% CI: -5.79 to -1.99; p < 0.0001).

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Implication

Systematic review quantifies exercise capacity reduction from pulmonary hypertension in interstitial lung disease, indicating significant health impacts.

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Torres-Castro et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5089f03e14405aa9c6a4 https://doi.org/10.1093/ajrccm/aamag162.2225

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A29-06 Effect of Pulmonary Hypertension on Exercise Capacity in Patients With Interstitial Lung Disease: A Systematic Review and Meta-Analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

A29-06 Effect of Pulmonary Hypertension on Exercise Capacity in Patients With Interstitial Lung Disease: A Systematic Review and Meta-Analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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