Key result
Chronic lower respiratory disease mortality complicated by respiratory failure increased ~0.4% annually since 1999.
Why the study?
Chronic lower respiratory diseases and respiratory failure remain leading causes of death in US adults, and understanding mortality trends across demographic and regional groups can inform prevention and policy priorities.
Population
1,438,986 recorded adult deaths from both CLRD and RF in the US
Comparison
Mortality trends across sex, race, ethnicity, age group, region, and locality
Design
Population-based retrospective study
Follow-up
25 years
Authors
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Slight rise in chronic respiratory mortality over 25 years warrants surveillance; leaves open drivers in this large cohort.
Observational (n=1,438,986)
Yes
Effect estimate: AAPC 0.40 (95% CI 0.10-0.69)
Mortality from CLRD complicated by respiratory failure in the US increased slightly between 1999 and 2023, with persistent disparities by geography, sex, and race.
Khan et al. (2026) conducted an observational in Chronic lower respiratory diseases and respiratory failure (n=1,438,986). Temporal trends was evaluated on Age-adjusted mortality rates (AAPC 0.40, 95% CI 0.10-0.69). Mortality from chronic lower respiratory disease complicated by respiratory failure increased slightly between 1999 and 2023 (AAPC 0.40; 95% CI 0.10-0.69), with persistent demographic disparities.
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