New fused tetracyclic ring systems: synthesis of 1-thia-4 a ,11,12-triazatetracenes via a multicomponent strategy, 2D-HMBC structural confirmation, and antimicrobial activity

Reham E. Abdelwahab; Mostafa E. Salem; Mohammed Rashed Alsulami; Mona M. Soliman; Ismail A. Abdelhamid; Amr M. Abdelmoniem; Faisal K. Algethami; Ahmed H. M. Elwahy

doi:10.1039/d6ra03008d

January 1, 2026RSC AdvancesOpen Access

New fused tetracyclic ring systems: synthesis of 1-thia-4 a ,11,12-triazatetracenes via a multicomponent strategy, 2D-HMBC structural confirmation, and antimicrobial activity

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Key Points

This research aims to synthesize new tetracyclic compounds and evaluate their antimicrobial properties.
Utilized a multicomponent strategy for the synthesis of 1-thia-4a,11,12-triazatetracenes.
Performed structural confirmation using 2D-HMBC techniques.
Conducted molecular docking studies to support antimicrobial activity.
Compound 9a showed promising broad-spectrum antimicrobial activity.
Molecular docking studies indicated strong binding affinity for target pathogens.

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Implication

Demonstrates antimicrobial activity in novel tetracyclic compounds, suggesting potential therapeutic applications.

Abstract

A novel multicomponent synthesis of tetracyclic 1-thia-4 a ,11,12-triazatetracenes exhibit promising antimicrobial activity, with compound 9a emerging as a potent broad-spectrum lead supported by molecular docking studies.

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Abdelwahab et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50aff03e14405aa9caa1 https://doi.org/10.1039/d6ra03008d

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New fused tetracyclic ring systems: synthesis of 1-thia-4 a ,11,12-triazatetracenes via a multicomponent strategy, 2D-HMBC structural confirmation, and antimicrobial activity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

New fused tetracyclic ring systems: synthesis of 1-thia-4 a ,11,12-triazatetracenes via a multicomponent strategy, 2D-HMBC structural confirmation, and antimicrobial activity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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