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This research aims to characterize the genome of Streptomyces globosus OSY-MM and its antimicrobial potential.

May 20, 2026Microbiology Resource Announcements0 citationsOpen Access

Draft genome of Streptomyces globosus OSY-MM, a broad-spectrum antimicrobial producer isolated from a cave in South Central Kentucky

GGGabriella J. GephartThe Ohio State University AAAhmed G. AbdelhamidMichigan State University MMMatthew J. MezydloThe Ohio State University

Key Points

This research aims to characterize the genome of Streptomyces globosus OSY-MM and its antimicrobial potential.
Isolated S. globosus OSY-MM from cave soil in South Central Kentucky.
Sequenced the genome resulting in 7,277,920 bp with 6,476 genes.
Identified biosynthetic gene clusters related to antibiotic production.
Demonstrated broad-spectrum antimicrobial activity of S. globosus OSY-MM.
Identified key biosynthetic gene clusters for streptothricin, kirromycin, and venezuelin-like antibiotics.

Abstract

ABSTRACT Streptomyces globosus OSY-MM was originally isolated from a soil sample collected from a cave in South Central Kentucky and was found to display strong, broad-spectrum antimicrobial activity. S. globosus OSY-MM has a 7,277,920 bp genome with 6,476 genes, including biosynthetic gene clusters encoding the production of streptothricin, kirromycin, and venezuelin-like antibiotics.

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