What question did this study set out to answer?

To highlight the occurrence of severe eosinophilia following chemotherapy that exacerbates asthma symptoms and to evaluate the treatment with benralizumab.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

C33-22 Chemotherapy-induced Eosinophilia Leading to Refractory Asthma Exacerbations Successfully Treated With Benralizumab

View Full Paper

Ask AI

Bookmark

Authors

PSP SrivastavaUniversity of Connecticut CSC ScottUniversity of Connecticut EBE L BernsteinThoughtventions Unlimited (United States)

Discussion

Member takes

Implication

Case report illustrates eosinophilia-induced asthma worsening in a cancer patient, treated successfully with benralizumab, indicating new therapeutic options.

Key Points

To highlight the occurrence of severe eosinophilia following chemotherapy that exacerbates asthma symptoms and to evaluate the treatment with benralizumab.
Described a case of a 48-year-old woman with metastatic HER2-positive breast cancer experiencing eosinophilia and refractory asthma exacerbations.
Administered benralizumab after corticosteroid therapies were inadequate and a multidisciplinary evaluation was conducted.
Monitored eosinophil counts and asthma symptoms over six months post-treatment.
Eosinophil count normalized from 8.1 × 109/L to baseline levels after benralizumab administration.
Patient's asthma symptoms improved significantly without further exacerbations over six months.
Demonstrated the potential for anti-IL-5 biologic therapy to control eosinophilia in chemotherapy patients.

Cite This Study

Srivastava et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50bdf03e14405aa9cc25 https://doi.org/10.1093/ajrccm/aamag162.578

View Full Paper

Ask AI

Bookmark

Implication

Case report illustrates eosinophilia-induced asthma worsening in a cancer patient, treated successfully with benralizumab, indicating new therapeutic options.

C33-22 Chemotherapy-induced Eosinophilia Leading to Refractory Asthma Exacerbations Successfully Treated With Benralizumab

Discussion

Member takes

Implication

Key Points

Cite This Study

C33-22 Chemotherapy-induced Eosinophilia Leading to Refractory Asthma Exacerbations Successfully Treated With Benralizumab

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider