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This study examines how the airway microbiome and mucosal immune responses interact in individuals with and without asthma.

Airway microbiome diversity, intra-mucosal bacteria, and spatial immunity in asthmatics and controls

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This study examines how the airway microbiome and mucosal immune responses interact in individuals with and without asthma.
Bronchoscopic sampling from 65 adult asthmatics and 44 healthy controls.
Quantification of bacterial operational taxonomic units using 16S rRNA sequencing.
Assessment of mucosal gene expression via Digital Spatial Profiling.
Asthma was predicted by basement membrane abnormalities and bacterial diversity; specific OTU abundances were not indicators.
Intra-mucosal bacteria negatively correlated with networks related to immunity and positively with basement membrane abnormalities.
Upregulation of regulatory T cell networks was observed in asthmatics.

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Randomized trial investigates airway microbiome interactions and immune responses in asthmatics, suggesting complex mucosal influences.

Moffatt et al. (2026) studied this question.

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