What question did this study set out to answer?

This study aims to determine how CC16 mRNA expression in different airway samples correlates with asthma burden and inflammation types.

D21-21 Bronchial Brushing Cc16 MRNA Expression as a Biomarker of Asthma Burden and Both Type 2 and Non-type 2 Inflammation in the U-biopred Study

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Randomized trial demonstrates CC16 mRNA as a biomarker for asthma severity and inflammation in adults, suggesting lower airway sampling is crucial.

This study aims to determine how CC16 mRNA expression in different airway samples correlates with asthma burden and inflammation types.
Analyzed data from 206 participants in the U-BIOPRED adult cohort.
Measured CC16 mRNA expression in bronchial brushings, biopsies, sputum, and nasal samples using microarray.
Conducted logistic and linear regression analyses to evaluate associations with asthma parameters.
Bronchial brushings showed the strongest negative correlation with asthma presence, severity, and symptom burden.
CC16 mRNA in bronchial brushings inversely associated with blood and sputum eosinophils and cytokine signatures.
Other airway samples showed weaker trends in association with asthma metrics.

Kimura et al. (2026) studied this question.

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Randomized trial demonstrates CC16 mRNA as a biomarker for asthma severity and inflammation in adults, suggesting lower airway sampling is crucial.