A66-01 Analysis on Clinical Characteristics and Risk Factors for Acute Pulmonary Embolism in Patients With Obstructive Sleep Apnea

Rationale The objectives of this study were to investigate the clinical characteristics and risk factors associated with acute pulmonary embolism (APE) in patients which were suffered from obstructive sleep apnea (OSA). Method: Clinical data were collected from 150 hospitalized patients diagnosed with OSA through polysomnography or home sleep monitoring at General Hospital of Ningxia Medical University between January 2022 and October 2024. Patients were divided into the APE group (n = 53) and the control group (n = 97) based on the development of APE. The APE group was further assessed using a simplified version of sPESI stratification, with sPESI≧1 indicating medium-to-high-risk (n = 33) and sPESI<1 indicating low risk (n = 20). Clinical data of the two groups were compared, and the risk factors for APE in OSA patients were analyzed using multivariate Logistic regression model. Results In the APE group, an increased proportion of patients with AHI≧15/h was observed, presenting statistically significant difference (P < 0.05). The levels of troponin I, fibrinogen, and D-dimer were significantly elevated in the APE group compared to the control group (P < 0.05). Compared to the control group, the right ventricular outflow tract, main pulmonary artery diameter, right ventricular anteroposterior diameter, and pulmonary artery systolic pressure (PASP) were also significantly increased in the APE group (P < 0.05). The multivariate analysis results demonstrated AHI, main pulmonary artery diameter, FIB, and D-dimer as independent risk factors for the development of pulmonary embolism. Furthermore, AUC curve analysis demonstrated that a main pulmonary artery diameter >26 mm, fibrinogen (FIB) >3.16 g/L, and D-dimer >1.74 mg/L were associated with a higher likelihood of APE, involving statistically significant difference (P < 0.05). APE was stratified, and statistical analysis was performed again. The results revealed increased levels of AHI, FIB, D-dimer, and main pulmonary artery diameter in patients with medium-to-high APE, and the difference was statistically significant compared to the control group (P < 0.05). Conclusion AHI, FIB, D-dimer, and main pulmonary artery diameter serve as independent risk factors for APE and are also associated with the progression to medium-to-high risk APE. This abstract is funded by: None