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May 20, 2026American Journal of Respiratory and Critical Care Medicine

A42-12 Drug-induced Pulmonary Arterial Hypertension From Over-the-counter Diet Pills and Methamphetamine Use

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Authors

FZF ZaiemCreighton UniversityMOM T OlsonSt. Joseph's Hospital and Medical CenterSRS Biswas RoySt. Joseph's Hospital and Medical Center

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Implication

Case report describes severe PAH due to chronic diet pill and methamphetamine use, indicating healthcare implications.

Key Points

  • To highlight the link between stimulant use and drug-induced pulmonary arterial hypertension (PAH).
  • Case description of a 53-year-old woman with progressive exertional dyspnea and peripheral edema.
  • Evaluation included transthoracic echocardiography, right heart catheterization, and exclusion of secondary PAH causes.
  • Initiation of triple therapy with monitoring of oxygen requirements and RVSP.
  • Severe precapillary pulmonary hypertension diagnosed with mean pulmonary artery pressure of 60 mmHg.
  • Right ventricular systolic pressure improved from 107 mmHg to approximately 40 mmHg at discharge.
  • Highlighting the need for awareness of drug-induced PAH and comprehensive substance use histories.

Cite This Study

Zaiem et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5100f03e14405aa9d4bfhttps://doi.org/10.1093/ajrccm/aamag162.2948
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A42-17 Methamphetamine-induced Combined Pre- and Post-capillary Pulmonary Hypertension in a Patient With Heart Failure and Bicuspid Aortic Valve2026
  2. 2An interesting case of pulmonary hypertension in nephrotic syndrome due to amphetamine use for attention-deficit hyperactivity disorder2023 · 1 citations
  3. 3PULMONARY VENO–OCCLUSIVE DISEASE ASSOCIATED WITH METHAMPHETAMINE ABUSE: A FIRST CASE DESCRIPTION2024
  4. 4Marked Improvement in Pulmonary Arterial Hypertension in 3 Patients with a History of Amphetamine-like Drug use and Comorbidities2026
  5. 5Methamphetamine‐Associated Pulmonary Arterial Hypertension: Impact, Mechanisms, and a Framework for Management2026 · 1 citations