What question did this study set out to answer?

This research aims to explore the paradoxical reductions in cardiac output observed in patients treated with sotatercept for pulmonary arterial hypertension despite improvements in hemodynamics.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

A19-04 Hemodynamic Heterogeneity in Sotatercept-Treated PAH: The Cardiac Output Paradox

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Authors

GSG StockdaleCleveland Clinic GHG A HeresiCleveland Clinic MSM SiubaCleveland Clinic

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Implication

Randomized trial investigates cardiac output in pulmonary arterial hypertension patients treated with sotatercept, suggesting unexpected outcomes.

Key Points

This research aims to explore the paradoxical reductions in cardiac output observed in patients treated with sotatercept for pulmonary arterial hypertension despite improvements in hemodynamics.
Retrospective analysis of patients who underwent right heart catheterization before and after sotatercept initiation.
Patients were grouped based on cardiac output response: decreased vs. maintained/increased CO.
Hemodynamic parameters and functional assessments were compared between groups.
Fifty patients with PAH were analyzed, with 30 (60%) showing decreased cardiac output after sotatercept therapy.
Patients with decreased CO had a lesser reduction in pulmonary vascular resistance: -20% compared to -46% for maintained/increased CO (p=0.001).
Functional improvements were comparable between groups despite differences in hemodynamic responses.

Cite This Study

Stockdale et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5114f03e14405aa9d640 https://doi.org/10.1093/ajrccm/aamag162.5480

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Implication

Randomized trial investigates cardiac output in pulmonary arterial hypertension patients treated with sotatercept, suggesting unexpected outcomes.

A19-04 Hemodynamic Heterogeneity in Sotatercept-Treated PAH: The Cardiac Output Paradox

Discussion

Member takes

Implication

Key Points

Cite This Study

A19-04 Hemodynamic Heterogeneity in Sotatercept-Treated PAH: The Cardiac Output Paradox

Discussion

Member takes

Implication

Key Points

Cite This Study

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