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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B79-14 Functional-immunological Changes in the Lungs of Apoe-/- Mice Following Repeated Exposure to Flaming Eucalyptus-Manzanita Smoke

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Authors

JOJ M OakesNortheastern UniversityCYC YazbeckNortheastern UniversityNMN MicovicNortheastern University

Discussion

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Implication

Randomized trial investigates lung function changes in mice exposed to wildfire smoke, suggesting immune response alterations.

Key Points

  • This study investigates how inhaling flaming wildfire smoke affects lung function and immune responses in Apoe-/- mice.
  • Apoe-/- mice were exposed to flaming wildfire smoke or filtered air for 2 hours daily over 7 days.
  • Bronchoalveolar lavage fluid was analyzed for immune cell types using flow cytometry.
  • Lung function was assessed through derecruitability tests and the constant phase model.
  • Significant increase in tissue elastance at intermediate PEEP levels in smoke-exposed mice.
  • Higher percentage of CD19+ B-cells and CD68+ macrophages observed after several days of smoke exposure.
  • Decreased proportions of Ly-6C- immune cells, indicating immunosuppressive effects.

Cite This Study

Oakes et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5132f03e14405aa9daa9https://doi.org/10.1093/ajrccm/aamag162.5264
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Also Consider

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  5. 5The effect of enriched versus depleted housing on eucalyptus smoke-induced cardiovascular dysfunction in mice2024 · 1 citations