Key result
Thyroid abnormalities, particularly low T3, are linked to worse prognosis in HF and AMI.
Why the study?
Recent experimental and clinical studies have highlighted the dialogue between the thyroid and heart in cardioprotection and the prognostic impact of thyroid alterations in cardiac disease.
This review highlights the prognostic importance of thyroid function alterations in patients with heart disease, emphasizing the potential need to treat these alterations to prevent cardiac events.
Answers are grounded in this paper and cite their sources.
Thyroid abnormalities identify higher-risk HF and AMI patients; hypothesis-generating and should not yet change practice.
The thyroid-heart relationship has a long and articulated history of its own, a history that en-compasses physiological and pathophysiological knowledge, the latter particularly in the context of cardiac diseases such as heart failure, arrhythmias and ischaemic heart disease. In recent years, molecular biology studies, in an experimental context, have highlighted the extraordinary dialogue that exists among the two systems in the field of cardioprotection, being an extremely important area for the treatment of cardiac diseases in both acute and chronic phases. In addi-tion, in the last few years, several studies have been carried out on the prognostic impact of al-terations in thyroid function, including subclinical ones, in heart disease, in particular in heart failure and acute myocardial infarction, with evidence of a negative prognostic impact of these and therefore with the suggestion to treat these alterations in order to prevent cardiac events, such as death. This review provides a comprehensive summary of the heart-thyroid relation-ship.
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Pingitore et al. (2023) conducted a review in Heart failure and acute myocardial infarction with thyroid abnormalities. Thyroid hormone abnormalities, particularly low T3 syndrome and subclinical dysfunction, exert a significant negative prognostic impact on patients with heart failure and acute myocardial infarction.
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