An 18 F-labeled ECL1i-Based C–C Chemokine Receptor Type 2 Radiotracer for Cardiac Inflammation Imaging

Key Result

An 18F-labeled ECL1i-based CCR2-targeted PET radiotracer demonstrates promise for imaging cardiac inflammation.

Key Points

• This research aims to develop and evaluate an ECL1i-based radiotracer for imaging cardiac inflammation.
• Developed an ¹⁸F-labeled ECL1i radiotracer
• Assessed receptor binding and imaging efficacy
• Conducted hybrid imaging studies in a modeled environment.
• The ECL1i radiotracer showed high specificity for C–C chemokine receptor type 2 (CCR2), facilitating accurate cardiac inflammation imaging.
• Imaging demonstrated a significant increase in tracer uptake in inflamed cardiac tissues compared to controls, with P<0.01 for statistical significance.