Key result
Ouabain (10^-5 M) depolarized isolated canine colonic myocytes and decreased input resistance from 0.487 to 0.292 G omega, causing an inward current averaging 71.06 pA.
Population
Isolated canine colonic myocytes
Comparison
Ouabain (10(-5) M) vs Baseline/control conditions
Design
Preclinical
Authors
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Supports electrogenic Na+ pump role in canine colonic myocyte potential; hypothesis-generating for human GI electrophysiology.
In canine colonic myocytes, an electrogenic Na+ pump contributes significantly to membrane potential, as evidenced by ouabain-induced depolarization and inward currents.
Burke et al. (1990) studied this question. Ouabain was evaluated on Passive membrane properties and voltage-dependent currents (input resistance and inward current). Ouabain (10^-5 M) depolarized isolated canine colonic myocytes and decreased input resistance from 0.487 to 0.292 G omega, causing an inward current averaging 71.06 pA.
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