Key result
Expressing recombinant elastin within the myocardial scar using cell-based gene therapy significantly reduced scar expansion, prevented LV enlargement, and preserved cardiac function (P<0.05).
Why the study?
Does cell-based gene therapy with the elastin gene improve cardiac function and reduce infarct size in a rat model of myocardial infarction?
Population
Rats with myocardial infarction generated by ligation of the left anterior descending artery, n=28
Comparison
2 x 10 syngeneic rat endothelial cells… vs 2 x 10 syngeneic rat endothelial cells…
Design
Preclinical
Follow-up
3 months
Authors
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Hypothesis-generating for post-MI elastin gene therapy; leaves open clinical translation pending larger animal and human studies.
Does cell-based gene therapy with the elastin gene improve cardiac function and reduce infarct size in a rat model of myocardial infarction?
p-value: p=<0.05
Cell-based gene therapy to express recombinant elastin in myocardial scars reduces scar expansion and preserves LV function in a rat model of myocardial infarction.
Mizuno et al. (2005) studied Myocardial infarction (n=28). Syngeneic rat endothelial cells transfected with the rat elastin gene vs. Empty plasmid was evaluated on Cardiac function, left ventricular (LV) volume, and infarct size (p=<0.05). Expressing recombinant elastin within the myocardial scar using cell-based gene therapy significantly reduced scar expansion, prevented LV enlargement, and preserved cardiac function (P<0.05).
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