Key result
Elastin-derived peptides and the Elastin Receptor Complex amplify cardiovascular risk factors and vascular alterations.
Why the study?
The involvement of elastin degradation products, named elastin-derived peptides, in Cardiovascular Continuum progression had not been considered before.
This review proposes a revisited Cardiovascular Continuum that incorporates the deleterious role of elastin degradation products and the Elastin Receptor Complex in cardiovascular and metabolic disease progression.
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May identify new intervention pathways; extends the Cardiovascular Continuum model pending clinical validation.
Wahart et al. (2019) conducted a review in Metabolic and cardiovascular diseases. Elastin-derived peptides and Elastin Receptor Complex was evaluated. Elastin-derived peptides and the Elastin Receptor Complex act as central regulators in the Cardiovascular Continuum, amplifying cardiovascular risk factors and vascular alterations.
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