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The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae ( P < 0.05) than against conidia (10%). Antagonism was not observed.
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Perkhofer et al. (2008) studied this question.
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