Key result
Whole blood viscosity independently predicts aortic stenosis severity at both low and high shear rates.
Why the study?
Whole blood viscosity may promote endothelial shear stress, inflammation, and atherosclerosis, but its relationship with aortic stenosis needed evaluation.
Observational (n=209)
Answers are grounded in this paper and cite their sources.
Whole blood viscosity is significantly elevated in patients with severe aortic stenosis and correlates with disease severity, suggesting a potential rheological component to the disease process.
Whole blood viscosity (WBV) may promote endothelial shear stress, inflammation, and can accelerate the atherosclerotic process. We aimed to evaluate the relationship between WBV and aortic stenosis. The study included 209 participants of whom 49 patients had severe aortic stenosis, 98 patients had mild-to-moderate aortic stenosis and 62 patients served as control. WBV values were significantly higher for high shear rate (HSR) (P = 0.001) and for low shear rate (LSR) (P = 0.002) in severe aortic stenosis group. HSR and LSR were correlated with mean systolic transaortic gradient (P < 0.001 and P < 0.001, respectively). WBV for both LSR and HSR were found to be independent predictors for the aortic stenosis severity (P = 0.034 and P = 0.049, respectively). We found a significant relationship between WBV and aortic stenosis.
No takes yet. Share an insight, caveat, or question.
Akdi et al. (2021) conducted an observational in Aortic stenosis (n=209). Whole blood viscosity vs. Controls and mild-to-moderate aortic stenosis was evaluated on Aortic stenosis severity (p=0.034 and 0.049). Whole blood viscosity for both low and high shear rates was an independent predictor of aortic stenosis severity (P=0.034 and P=0.049, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: