Key result
TAVI and bAVR linked to similar reductions in whole blood viscosity at 3 months.
Why the study?
Whole blood viscosity reflects hemodynamic load and blood flow, but its changes following percutaneous and surgical interventions for aortic stenosis required investigation.
Do percutaneous or surgical interventions for aortic stenosis reduce whole blood viscosity?
Cohort (n=200)
Do percutaneous or surgical interventions for aortic stenosis reduce whole blood viscosity?
Both TAVI and surgical AVR significantly reduce whole blood viscosity at 3 months, suggesting WBV could be a useful biomarker for monitoring post-intervention hemorheological changes.
Answers are grounded in this paper and cite their sources.
Post-AVR WBV reductions support biomarker monitoring; leaves open whether changes affect outcomes or guide therapy.
Objective Aortic stenosis is a common valvular disease in the elderly. This study aimed to investigate changes in whole blood viscosity (WBV), which reflects hemodynamic load and blood flow and is associated with cardiovascular diseases, after percutaneous and surgical interventions for aortic stenosis. Methods From 2019 to 2022, 200 patients undergoing Transcatheter Aortic Valve Implantation (TAVI) (n = 100) or bioprosthetic Aortic Valve Replacement (bAVR) (n = 100) were analyzed. WBV at low shear rate (LSR, 0.5 s −1 ) and high shear rate (HSR, 208 s −1 ) was calculated from the hematocrit and total protein using the De Simone formula. Pre- and 3-month values were compared using paired and independent t-tests, and correlations and multivariable regression were performed. Results The aortic valve area was negatively correlated with HSR (r = –0.340, p < 0.01) and LSR (r = –0.358, p < 0.01). At 3 months, HSR decreased by 0.95 ± 0.31 cP and LSR by 18.92 ± 6.32 cP (both p < 0.001). Reductions were significant in both groups without between-group differences and were mainly related to decreases in non-albumin protein fractions. Conclusion Both TAVI and bAVR markedly reduced WBV, independent of the intervention type. WBV may be a useful biomarker for monitoring hemorheological and protein-based changes following valve intervention.
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Güner et al. (2026) conducted a cohort in Aortic stenosis (n=200). Transcatheter Aortic Valve Implantation (TAVI) vs. bioprosthetic Aortic Valve Replacement (bAVR) was evaluated on Changes in whole blood viscosity (WBV) at low and high shear rates (p=<0.001). Both TAVI and bioprosthetic aortic valve replacement significantly reduced whole blood viscosity at 3 months (HSR decreased by 0.95 cP, LSR by 18.92 cP; p<0.001), with no between-group differences.
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