Key result
Zero-dimensional cardiovascular model accurately simulates severe AS, estimating an effective orifice area of ~0.61 cm2.
Why the study?
To develop a zero-dimensional cardiovascular system model based on an electrical analogy capable of simulating normal and diseased conditions, particularly aortic stenosis, and evaluate parameter effects on hemodynamics.
A 14-compartment zero-dimensional cardiovascular model can accurately simulate the hemodynamic relationship between effective orifice area and mean pressure gradient across varying severities of aortic stenosis.
Requires clinical validation before patient application; leaves open refinement of zero-dimensional models for aortic stenosis hemodynamics.
This work presents a developed zero-dimensional cardiovascular (CV) system model, based on an electrical analogy, with a detailed compartmental description of the heart and the main vascular circulation which is able to simulate normal and diseased conditions of CV system, especially the stenosis valvular aortic. To know the effect of each parameter on hemodynamics, the number of parameters is increased by adding more segments. The developed model consists of 14 compartments. The results show that the severity of aortic stenosis (AS) effect varies with the effective orifice area and the mean pressure gradient for the case of no AS; the effective orifice area is 4[Formula: see text]cm 2 and the mean pressure gradient is 0[Formula: see text]mmHg, while for the case of mild AS, the effective orifice area is 1.5[Formula: see text]cm 2 and the mean pressure gradient is 27.24[Formula: see text]mmHg. For the case of moderate AS, the effective orifice area is 1.0[Formula: see text]cm 2 and the mean pressure gradient is 44.68[Formula: see text]mmHg. For the case of the severe AS, the effective orifice area is 0.61[Formula: see text]cm 2 and the mean pressure gradient is 77.51[Formula: see text]mmHg. It is found that the developed model can estimate an accurate value of the effective orifice area for any value of mean pressure gradient in AS. The results obtained for the CV system under normal and diseased conditions show a good agreement compared to published results.
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HALAIMI et al. (2020) studied Aortic stenosis. Zero-dimensional cardiovascular system model vs. Normal cardiovascular system was evaluated on Effective orifice area and mean pressure gradient. A zero-dimensional cardiovascular model accurately simulated aortic stenosis, estimating an effective orifice area of 0.61 cm2 for a mean pressure gradient of 77.51 mmHg in severe cases.
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