Key result
Inhibition of ETA receptors by darusentan reversed aortic alterations, including increases in medial cell number and accumulation of collagen and elastin, produced by norepinephrine infusion in rats.
Why the study?
Does darusentan reverse norepinephrine-induced aortic remodeling in rats?
Population
Rats treated with norepinephrine (2.5 microg/Kg per min subcutaneously) to induce aortic remodeling
Comparison
Darusentan 30 mg/Kg per day orally for weeks 3… vs Norepinephrine infusion alone
Design
Preclinical
Follow-up
4 weeks
Authors
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Hypothesis-generating for ETA antagonism in sympathetic vascular remodeling; leaves open translation to human disease.
Does darusentan reverse norepinephrine-induced aortic remodeling in rats?
Endothelin-A receptor antagonism with darusentan reverses norepinephrine-induced aortic remodeling in rats, suggesting a potential therapeutic role in conditions with elevated catecholamines.
Dao et al. (2001) studied Norepinephrine-induced aortic remodeling. Darusentan (LU135252) vs. Norepinephrine alone was evaluated on Aortic structural and compositional changes (medial cell number, collagen, elastin). Inhibition of ETA receptors by darusentan reversed aortic alterations, including increases in medial cell number and accumulation of collagen and elastin, produced by norepinephrine infusion in rats.
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