Serum Inorganic Phosphorus Levels in Males and Females at Progressive Ages, With Concomitant Measurements of Urinary Ketosteroids and Androgens in Men*

The level of serum inorganic phosphorus (SIP) has been observed to increase after castration of young adult males (1). As tested in 9 subjects, the mean change reached statistically significant levels within fifteen days following orchiectomy and persisted for four years, at which time the study was discontinued. Six of the 9 subjects exhibited marked increases in SIP; the remaining 3 along with 3 males in another series, had high values prior to castration, and removal of their testes resulted either in only slight elevation of the SIP level or a decrease after three or four years.