Key result
Ankle-Brachial Index showed a significant inverse correlation with vascular stiffness assessed by augmentation index in patients without peripheral artery disease (P=0.002).
Why the study?
Does the Ankle-Brachial Index correlate with arterial stiffness in patients without peripheral artery disease?
Cross-Sectional (n=55)
Does the Ankle-Brachial Index correlate with arterial stiffness in patients without peripheral artery disease?
In patients without peripheral artery disease, ABI inversely correlates with arterial stiffness measured by augmentation index, suggesting its potential utility in cardiovascular risk assessment.
Supports ABI for stiffness assessment in non-PAD; leaves open prospective validation for risk stratification.
We tested the hypothesis that the Ankle-Brachial Index (ABI) in patients without peripheral arterial disease ([PAD] ABI > 1.0) is an indicator of arterial stiffness. Fifty-five patients had measurement of carotid pulse wave contour, pulse wave velocity (PWV), and ABI. Vascular stiffness as assessed by augmentation index (AIx) showed a significant (P = .002) inverse correlation with ABI. Dichotomizing ABI into groups above and below the median showed that persons with a lower ABI, >1.0 to 1.5 (n = 27) had a significantly (P < .01) higher AIx than those with a higher ABI > 1.5 (n = 28). In contrast, vascular stiffness assessed by brachial-ankle or carotid femoral PWV did not correlate with ABI. In summary, ABI is an indicator of arterial stiffness assessed by AIx. Vascular changes detected by AIx are not the same as those detected by PWV. Assessment of ABI may have utility in cardiovascular risk assessment in patients without PAD.
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Rabkin et al. (2011) conducted a cross-sectional in Patients without peripheral arterial disease (n=55). Ankle-Brachial Index (ABI) was evaluated on Correlation between ABI and vascular stiffness assessed by augmentation index (AIx) (p=.002). Ankle-Brachial Index showed a significant inverse correlation with vascular stiffness assessed by augmentation index in patients without peripheral artery disease (P=0.002).
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