Ankle-Brachial Index and Subclinical Cardiac and Carotid Disease
Why the study?
Does lower ankle-brachial index associate with increased subclinical cardiac and carotid disease in individuals free of clinically evident cardiovascular disease?
Population
6,570 individuals free of clinically evident cardiovascular disease from the Multi-Ethnic Study of…
Comparison
Lower or higher ankle-brachial index categories… vs Normal ABI (1.10-1.29)
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Lower ABI may flag higher subclinical coronary risk even in low-normal ranges; extends cross-sectional associations but leaves prospective validation and thresholds open.
Structured PICO
Does lower ankle-brachial index associate with increased subclinical cardiac and carotid disease in individuals free of clinically evident cardiovascular disease?
P
Population
6,570 individuals (3,458 women, average age 62.6 years; 3,112 men, average age 62.8 years) free of clinically evident cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis.
I
Intervention
Lower or higher ankle-brachial index (ABI) categories: <0.90 (definite peripheral arterial disease), 0.90-0.99 (borderline ABI), 1.00-1.09 (low-normal ABI), and >=1.30 (high ABI)
C
Comparator
Normal ABI (1.10-1.29)
O
Outcome
Carotid artery intima-media thickness and coronary artery calcium assessed with computed tomographysurrogate
ABI values below 1.10 in men and 1.00 in women are associated with excess coronary and carotid atherosclerosis, suggesting increased cardiovascular risk even in borderline and low-normal ABI ranges.
Cite This Study
Mcdermott et al. (2005) studied this question.