What question did this study set out to answer?

Quantify changes in left ventricular three-dimensional geometry, wall thickness, and valve dimensions under controlled hemodynamic conditions during systole and diastole.

October 1, 1967Circulation Research

The Architecture of the Heart in Systole and Diastole

Q: What is the clinical evidence from this study?

Study design: Other. Population: Canine left ventricular geometry (n=20). Intervention: Rapid fixation in systole or diastole vs. Comparison between end diastole, end ejection, and overdistension. Primary outcome: Ventricular geometry and architecture measurements.

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Key result

Rapid fixation of canine left ventricles showed that from end diastole to end ejection, the minor internal equator reduced by 26% and average wall thickness increased by 28%.

Population

20 canine left ventricles

Comparison

Rapid fixation of the canine left ventricle in… vs Comparison between systolic and diastolic…

Design

Preclinical

Authors

JRJohn RossUniversité de Technologie de Compiègne ESEdmund H. SonnenblickUniversity of Parma JCJames W. CovellBoston University

Discussion

Member takes

Implication

Informs LV contraction models; extends preclinical geometry data but leaves human applicability open.

Key Points

Quantify changes in left ventricular three-dimensional geometry, wall thickness, and valve dimensions under controlled hemodynamic conditions during systole and diastole.
Rapidly fixed canine left ventricles under defined pressures at end diastole (n=6), end ejection (n=7), and post-overdistension diastole (n=7).
Analyzed ventricular dimensions and architecture using direct anatomical measurements and silicone-rubber internal cavity casts.
From end diastole to end ejection, the minor internal equator decreased by 26%, midwall radius decreased by 16%, outer radius decreased by 8.5%, and apex-to-mitral distance shortened by 4.6%, whereas apex-to-aortic distance changed by <1%.
Average ventricular wall thickness was 28% greater in systole than in diastole, with the stroke volume to end-diastolic volume ratio averaging 59%.
Mitral valve orifice area decreased by 28% at end systole compared with end diastole, but increased by 39% in hearts subjected to acute volume overload.

Structured PICO

Population

20 canine left ventricles (6 arrested at end diastole, 7 at end ejection, 7 in diastole following acute ventricular overdistension)

Intervention

Rapid fixation of the canine left ventricle in systole or diastole

Comparator

Comparison between systolic and diastolic states, and normal versus overdistended states

Outcome

Ventricular geometry (measurements of fixed ventricles and silicone-rubber casts)surrogate

This preclinical study provides detailed geometric measurements of the canine left ventricle in systole and diastole, offering a framework for modeling left ventricular contraction mechanics.

Cite This Study

Ross et al. (1967) studied Canine left ventricular geometry (n=20). Rapid fixation in systole or diastole vs. Comparison between end diastole, end ejection, and overdistension was evaluated on Ventricular geometry and architecture measurements. Rapid fixation of canine left ventricles showed that from end diastole to end ejection, the minor internal equator reduced by 26% and average wall thickness increased by 28%.

synapsesocial.com/papers/6a0d6ea0cae7912d2fa4ffee https://doi.org/10.1161/01.res.21.4.409

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October 1, 1967Circulation Research

The Architecture of the Heart in Systole and Diastole

View Full Paper

Ask AI

Bookmark

Key result

Rapid fixation of canine left ventricles showed that from end diastole to end ejection, the minor internal equator reduced by 26% and average wall thickness increased by 28%.

Population

20 canine left ventricles

Comparison

Rapid fixation of the canine left ventricle in… vs Comparison between systolic and diastolic…

Design

Preclinical

Authors

JRJohn RossUniversité de Technologie de Compiègne ESEdmund H. SonnenblickUniversity of Parma JCJames W. CovellBoston University

Discussion

Member takes

Implication

Informs LV contraction models; extends preclinical geometry data but leaves human applicability open.

Key Points

Quantify changes in left ventricular three-dimensional geometry, wall thickness, and valve dimensions under controlled hemodynamic conditions during systole and diastole.
Rapidly fixed canine left ventricles under defined pressures at end diastole (n=6), end ejection (n=7), and post-overdistension diastole (n=7).
Analyzed ventricular dimensions and architecture using direct anatomical measurements and silicone-rubber internal cavity casts.
From end diastole to end ejection, the minor internal equator decreased by 26%, midwall radius decreased by 16%, outer radius decreased by 8.5%, and apex-to-mitral distance shortened by 4.6%, whereas apex-to-aortic distance changed by <1%.
Average ventricular wall thickness was 28% greater in systole than in diastole, with the stroke volume to end-diastolic volume ratio averaging 59%.
Mitral valve orifice area decreased by 28% at end systole compared with end diastole, but increased by 39% in hearts subjected to acute volume overload.

Structured PICO

Population

20 canine left ventricles (6 arrested at end diastole, 7 at end ejection, 7 in diastole following acute ventricular overdistension)

Intervention

Rapid fixation of the canine left ventricle in systole or diastole

Comparator

Comparison between systolic and diastolic states, and normal versus overdistended states

Outcome

Ventricular geometry (measurements of fixed ventricles and silicone-rubber casts)surrogate

This preclinical study provides detailed geometric measurements of the canine left ventricle in systole and diastole, offering a framework for modeling left ventricular contraction mechanics.

Cite This Study

synapsesocial.com/papers/6a0d6ea0cae7912d2fa4ffee https://doi.org/10.1161/01.res.21.4.409

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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